Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8245945 | 0.81 | POLB (0.62) | POLBTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9290603 | 0.78 | POLB (0.66) | POLBTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7874774 | 0.75 | FFAR2 (0.53) | POLBSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL12599386 | 0.74 | CA1 (0.58) | POLBTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7876547 | 0.73 | FFAR2 (0.52) | POLBSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL21222557 | 0.73 | TP53 (0.66) | POLBTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2629359 | 0.71 | SMN1; SMN2 (0.65) | POLBTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL19295803 | 0.71 | TP53 (0.52) | POLBTP53SMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL3523296 | 0.70 | TP53 (0.58) | POLBTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL15386264 | 0.70 | CA1 (0.61) | POLBTP53SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |