Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 10/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13156686 | 0.79 | CCNE1 (0.68) | FFAR2RAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5875694 | 0.77 | FFAR2 (0.48) | FFAR2RAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL2880446 | 0.76 | RAB9A (0.56) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL26818237 | 0.75 | RAB9A (0.58) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL7868167 | 0.75 | POLB (0.54) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL3794688 | 0.75 | RAB9A (0.62) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL6056907 | 0.74 | HSPA5 (0.57) | FFAR2NPC1MEN1KMT2ALMNA | |
| SCHEMBL4119851 | 0.74 | HSPA5 (0.57) | FFAR2NPC1MEN1KMT2ALMNA | |
| SCHEMBL19449891 | 0.74 | NPC1 (0.49) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL2175131 | 0.73 | RAB9A (0.60) | RAB9ASMN1; SMN2NPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |