SCHEMBL786883

SCHEMBL786883

CCCC[Si](C)(C)O[Si](C)(C)CCCC(CC(=O)O)C(=O)O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.44
MAPK1 P28482 1/20 0.44
FOLH1 Q04609 1/20 0.42
SLC1A2 P43004 2/20 0.39
SLC1A1 P43005 2/20 0.39
SLC1A3 P43003 1/20 0.39
GRIK1 P39086 2/20 0.38
GRIK2 Q13002 2/20 0.38
GPR84 Q9NQS5 4/20 0.38
CHRM1 P11229 1/20 0.37
AKR1A1 P14550 1/20 0.37
CHRM3 P20309 1/20 0.37
HTR2A P28223 1/20 0.37
HTR2C P28335 1/20 0.37
ADRA1A P35348 1/20 0.37
HRH1 P35367 1/20 0.37
DRD3 P35462 1/20 0.37
SLC6A3 Q01959 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC2 Q92769 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13756261 0.94 FOLH1 (0.47) CA2MAPK1FOLH1SLC1A2SLC1A1
SCHEMBL786932 0.87 FOLH1 (0.44) CA2MAPK1FOLH1SLC1A2SLC1A1
SCHEMBL13151579 0.86 FOLH1 (0.43) CA2MAPK1FOLH1SLC1A2SLC1A1
SCHEMBL13318396 0.82 FOLH1 (0.38) CA2MAPK1FOLH1
SCHEMBL20492090 0.82 FOLH1 (0.46) CA2MAPK1FOLH1SLC1A2SLC1A1
SCHEMBL13042922 0.82 GPR84 (0.42) CA2MAPK1FOLH1SLC1A2SLC1A1
SCHEMBL786940 0.79 GPR84 (0.46) CA2MAPK1FOLH1SLC1A2SLC1A1
SCHEMBL786970 0.79 GPR84 (0.46) CA2MAPK1FOLH1SLC1A2SLC1A1
SCHEMBL306773 0.79 CA2 (0.68) CA2MAPK1FOLH1SLC1A2SLC1A1
SCHEMBL9590977 0.79 CA2 (0.68) CA2MAPK1FOLH1SLC1A2SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150166342-A1 Functionalized Matrices for Dispersion of Nanostructures NANOSYS, INC. (US) 2015-06-18 US disclosed
US-8916064-B2 Functionalized matrices for dispersion of nanostructures NANOSYS, INC. (US) 2014-12-23 US disclosed
US-20140151600-A1 Functionalized Matrices for Dispersion of Nanostructures NANOSYS, INC. (US) 2014-06-05 US disclosed
US-8425803-B2 Nanocrystal doped matrixes SAMSUNG ELECTRONICS CO., LTD. (KR) 2013-04-23 US disclosed
US-20130043433-A1 Functionalized Matrixes for Dispersion of Nanostructures NANOSYS, INC. (US) 2013-02-21 US disclosed
US-8283412-B2 Functionalized matrices for dispersion of nanostructures NANOSYS, INC. (US) 2012-10-09 US disclosed
US-20120068118-A1 NANOCRYSTAL DOPED MATRIXES SAMSUNG ELECTRONICS CO., LTD. (KR) 2012-03-22 US disclosed
US-20100276638-A1 Functionalized matrixes for dispersion of nanostructures NANOSYS, INC. (US) 2010-11-04 US disclosed
US-20100140551-A1 Nanocrystal doped matrixes NANOSYS, INC. (US) 2010-06-10 US disclosed
US-7645397-B2 Luminescent nanocomposite of luminescent nanocrystalline embedded in an epoxy, polyurea, or polyurethane matrix; retain luminescence; surfaces of nanocrystals having bound ligands comprising dicarboxylic acid moiety or aliphatic or polymeric amines; high efficiency solid-state white lighting; optics NANOSYS, INC. (US) 2010-01-12 US disclosed
US-20070034833-A1 Luminescent nanocomposite of luminescent nanocrystalline embedded in an epoxy, polyurea, or polyurethane matrix; retain luminescence; surfaces of nanocrystals having bound ligands comprising dicarboxylic acid moiety or aliphatic or polymeric amines; high efficiency solid-state white lighting; optics NANOSYS, INC. 2007-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100276638-A1 Functionalized matrixes for dispersion of nanostructures STRA6, EPHA6, MIF CA2 3459/4885MAPK1 2565/4885FOLH1 3721/4885
US-20120068118-A1 NANOCRYSTAL DOPED MATRIXES STRA6, EPHA6, PIR CA2 2532/4885MAPK1 2304/4885FOLH1 4010/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.