Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Quinalizarin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.76 |
| ▸ | MAOA | P21397 | 6/20 | 0.76 |
| ▸ | HPGD | P15428 | 6/20 | 0.76 |
| ▸ | MEN1 | O00255 | 5/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.76 |
| ▸ | RECQL | P46063 | 3/20 | 0.76 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.76 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.76 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.76 |
| ▸ | CSNK2A3 | Q8NEV1 | 3/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.76 |
| ▸ | APEX1 | P27695 | 2/20 | 0.76 |
| ▸ | TP53 | P04637 | 2/20 | 0.76 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinalizarin SCHEMBL20608650 | 0.87 | MAOA (1.00) | MAPTMAOAHPGDMEN1KMT2A | |
| Quinalizarin SCHEMBL138122 | 0.87 | MAOA (1.00) | MAPTMAOAHPGDMEN1KMT2A | |
| Quinalizarin SCHEMBL29437816 | 0.87 | MAOA (1.00) | MAPTMAOAHPGDMEN1KMT2A | |
| Quinalizarin SCHEMBL29516323 | 0.87 | MAOA (1.00) | MAPTMAOAHPGDMEN1KMT2A | |
| SCHEMBL2772226 | 0.81 | MAPT (0.86) | MAPTMAOAHPGDMEN1KMT2A | |
| SCHEMBL17689250 | 0.81 | MEN1 (0.79) | MAPTMAOAHPGDMEN1KMT2A | |
| SCHEMBL6904748 | 0.79 | MAPT (0.83) | MAPTMAOAHPGDMEN1KMT2A | |
| SCHEMBL11055115 | 0.77 | MAPT (0.80) | MAPTMAOAHPGDMEN1KMT2A | |
| SCHEMBL14680732 | 0.77 | ELANE (0.72) | MAPTMAOAHPGDMEN1KMT2A | |
| SCHEMBL23866703 | 0.75 | MEN1 (0.70) | MAPTMAOAHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153953-A1 | POLYMERIZATION CATALYST FOR POLYESTER PRODUCTION, POLYESTER, AND PROCESS FOR PRODUCING POLYESTER | Toyo Boseki Kabushiki Kaisha (JP) | 2001-11-14 | — | — | EP | disclosed |