Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874302 | 0.77 | REN (0.52) | RENCYP3A4KCNH2HTR2A | |
| SCHEMBL556389 | 0.73 | REN (0.80) | RENCYP3A4KCNH2 | |
| SCHEMBL20951890 | 0.60 | NR1H4 (0.46) | RENCYP3A4KCNH2 | |
| SCHEMBL7871427 | 0.59 | REN (0.56) | RENCYP3A4KCNH2HTR2A | |
| SCHEMBL4500623 | 0.58 | SLC6A2 (0.54) | KCNH2 | |
| SCHEMBL7862960 | 0.58 | KCNH2 (0.42) | RENKCNH2HTR2A | |
| SCHEMBL4506607 | 0.58 | SLC6A2 (0.46) | RENCYP3A4KCNH2 | |
| SCHEMBL3903970 | 0.56 | GRK2 (0.44) | CYP3A4KCNH2HTR2AHTR2CHTR2B | |
| SCHEMBL19459164 | 0.56 | FPR1 (0.41) | RENKCNH2HTR2AHTR2CHTR2B | |
| SCHEMBL1058913 | 0.56 | SLC6A2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |