Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | SGMS1 | Q86VZ5 | 5/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869424 | 0.92 | POLB (0.47) | POLBPTPN1SGMS1BCL2L1MCL1 | |
| SCHEMBL7870440 | 0.91 | PTPN1 (0.49) | POLBPTPN1SGMS1BCL2L1MCL1 | |
| SCHEMBL7862849 | 0.91 | CA2 (0.43) | BCL2L1MCL1ALDH1A1SMN1; SMN2OPRM1 | |
| SCHEMBL8867954 | 0.89 | POLB (0.47) | POLBPTPN1SGMS1BCL2L1MCL1 | |
| SCHEMBL7867954 | 0.88 | POLB (0.50) | POLBPTPN1SGMS1BCL2L1MCL1 | |
| SCHEMBL7867901 | 0.87 | EGFR (0.39) | LMNAGAAOPRM1OPRD1 | |
| SCHEMBL9018028 | 0.86 | PTPN1 (0.53) | POLBPTPN1SGMS1BCL2L1MCL1 | |
| SCHEMBL7867688 | 0.86 | SMN1; SMN2 (0.46) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL9018186 | 0.85 | POLB (0.51) | POLBPTPN1SGMS1BCL2L1MCL1 | |
| SCHEMBL7874497 | 0.84 | MAPT (0.47) | BCL2L1MCL1ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |