Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7870590 | 0.92 | MAPT (0.49) | MAPTEPHX2MEN1KMT2AGABRA5 | |
| SCHEMBL7874555 | 0.91 | MAPT (0.51) | MAPTEPHX2MEN1KMT2AGABRA5 | |
| SCHEMBL7867688 | 0.91 | SMN1; SMN2 (0.46) | MAPTMEN1KMT2ACA12CA1 | |
| SCHEMBL7867901 | 0.90 | EGFR (0.39) | EPHX2MEN1KMT2ACA1CA2 | |
| SCHEMBL8868128 | 0.89 | MAPT (0.49) | MAPTMEN1KMT2ABCL2L1MCL1 | |
| SCHEMBL7869433 | 0.87 | MAPT (0.50) | MAPTEPHX2MEN1KMT2AGABRA5 | |
| SCHEMBL7870592 | 0.87 | MAPT (0.50) | MAPTEPHX2MEN1KMT2AGABRA5 | |
| SCHEMBL7862849 | 0.86 | CA2 (0.43) | EPHX2BCL2L1MCL1CA12CA1 | |
| SCHEMBL9018049 | 0.85 | MAPT (0.54) | MAPTEPHX2MEN1KMT2ABCL2L1 | |
| SCHEMBL9018181 | 0.85 | MAPT (0.54) | MAPTEPHX2MEN1KMT2ABCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |