Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA7 | P43166 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874565 | 0.94 | PPARA (0.46) | PPARASMN1; SMN2ALDH1A1LMNANAMPT | |
| SCHEMBL7862676 | 0.94 | RAB9A (0.46) | SMN1; SMN2ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL7874604 | 0.92 | RAB9A (0.44) | SMN1; SMN2ALDH1A1LMNANAMPTNPC1 | |
| SCHEMBL7867914 | 0.92 | SMN1; SMN2 (0.46) | PPARASMN1; SMN2ALDH1A1LMNANAMPT | |
| SCHEMBL7867710 | 0.91 | NLRP3 (0.54) | SMN1; SMN2ALDH1A1LMNANAMPTMEN1 | |
| SCHEMBL7862882 | 0.91 | EGFR (0.52) | PPARASMN1; SMN2LMNANAMPTNPC1 | |
| SCHEMBL7869432 | 0.91 | EGFR (0.52) | PPARASMN1; SMN2LMNANAMPTNPC1 | |
| SCHEMBL7862721 | 0.91 | RAB9A (0.50) | PPARASMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL9018279 | 0.90 | PPARA (0.49) | PPARASMN1; SMN2ALDH1A1LMNANAMPT | |
| SCHEMBL7871648 | 0.90 | RAB9A (0.39) | SMN1; SMN2ALDH1A1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |