Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.40 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | QDPR | P09417 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11874262 | 0.77 | HTR6 (0.55) | HTR6SLC6A4KDM4ELMNAPOLB | |
| Bromide SCHEMBL7859846 | 0.74 | SLC6A4 (0.62) | HTR6SLC6A4KDM4ELMNAPOLB | |
| Bromide SCHEMBL7867557 | 0.72 | SLC6A4 (0.40) | HTR6SLC6A4KDM4ELMNAPOLB | |
| SCHEMBL158017 | 0.70 | SLC6A4 (0.47) | HTR6SLC6A4KDM4ELMNAPOLB | |
| Bromide SCHEMBL7870911 | 0.69 | SLC6A4 (0.54) | HTR6SLC6A4KDM4ELMNAPOLB | |
| Bromide SCHEMBL7870790 | 0.69 | HTR6 (0.47) | HTR6SLC6A4KDM4ELMNAPOLB | |
| Bromide SCHEMBL7870832 | 0.69 | SLC6A4 (0.57) | HTR6SLC6A4KDM4ELMNAPOLB | |
| Oxalic Acid SCHEMBL7867378 | 0.68 | SLC6A4 (0.52) | HTR6SLC6A4 | |
| SCHEMBL7866280 | 0.68 | SLC6A4 (0.64) | HTR6SLC6A4KDM4ELMNAPOLB | |
| SCHEMBL7000439 | 0.68 | SLC6A4 (0.42) | HTR6SLC6A4KDM4ELMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |