Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.47 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7864959 | 0.89 | DRD2 (0.47) | MAPTTP53THRBDRD2SLC6A4 | |
| SCHEMBL22860673 | 0.83 | MAPT (0.52) | MAPTTP53THRBDRD2SLC6A4 | |
| SCHEMBL6992781 | 0.82 | HTR1D (0.56) | MAPTTHRBDRD2SLC6A4HTR1B | |
| SCHEMBL7867551 | 0.81 | DRD2 (0.44) | DRD2SLC6A4OPRL1HTR1BHTR6 | |
| SCHEMBL11877059 | 0.78 | SLC6A4 (0.72) | MAPTTP53DRD2SLC6A4 | |
| SCHEMBL13927335 | 0.77 | MAPT (0.46) | MAPTTP53THRBDRD2SLC6A4 | |
| Maleic Acid SCHEMBL8820356 | 0.76 | HTR7 (0.42) | MAPTTP53THRBDRD2HTR1B | |
| SCHEMBL4975027 | 0.76 | GRM2 (0.47) | DRD2SLC6A4OPRL1 | |
| Bromide SCHEMBL8820697 | 0.76 | SLC6A4 (0.38) | DRD2SLC6A4 | |
| SCHEMBL13927332 | 0.73 | MAPT (0.38) | MAPTTP53THRBLMNAMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |