Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 7/20 | 0.38 |
| ▸ | SLC6A2 known ✓ | P23975 | 6/20 | 0.38 |
| ▸ | SLC6A3 known ✓ | Q01959 | 6/20 | 0.38 |
| ▸ | HTR1A known ✓ | P08908 | 5/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.38 |
| ▸ | CDK9 | P50750 | 7/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | CASP7 | P55210 | 2/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7866276 | 0.85 | HTR2C (0.44) | SLC6A4SLC6A2SLC6A3HTR1AHTR2C | |
| Bromide SCHEMBL7864959 | 0.82 | DRD2 (0.47) | SLC6A4HTR1AAVPR2AVPR1AAVPR1B | |
| SCHEMBL7468044 | 0.79 | SLC6A2 (0.44) | SLC6A4SLC6A2SLC6A3HTR1AAPP | |
| Bromide SCHEMBL8818387 | 0.78 | APP (0.54) | SLC6A4HTR1AAPPDRD2 | |
| Hydrochloric Acid SCHEMBL1673605 | 0.78 | SLC6A2 (0.43) | SLC6A4SLC6A2SLC6A3HTR1AHTR2C | |
| Bromide SCHEMBL7870846 | 0.76 | MAPT (0.47) | SLC6A4DRD2 | |
| SCHEMBL14573110 | 0.74 | SLC6A2 (0.40) | SLC6A4SLC6A2SLC6A3HTR1AHTR2C | |
| SCHEMBL7867551 | 0.74 | DRD2 (0.44) | SLC6A4APPDRD2 | |
| SCHEMBL694609 | 0.70 | AVPR2 (0.40) | SLC6A4AVPR2AVPR1AAVPR1BDRD2 | |
| Bromide SCHEMBL8820626 | 0.69 | CDK9 (0.45) | CCNT1CDK9CASP3CASP7CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997047302-A1 | INHIBITION OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1997-12-18 | — | — | WO | disclosed |