Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.63 |
| ▸ | TGM2 | P21980 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1263966 | 0.82 | THRB (0.61) | THRBTHRA | |
| SCHEMBL1263947 | 0.82 | THRB (0.61) | THRBTHRA | |
| SCHEMBL15114278 | 0.80 | MAPT (0.58) | KMT2AMEN1MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL10086611 | 0.80 | THRB (0.53) | THRBTGM2KMT2AMEN1MAPT | |
| SCHEMBL9568488 | 0.79 | HPGD (0.54) | THRBTGM2MAPTSMN1; SMN2LMNA | |
| SCHEMBL2587522 | 0.79 | THRB (0.64) | THRBTGM2KMT2AMEN1MAPT | |
| SCHEMBL18994205 | 0.79 | KMT2A (0.43) | THRBKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL20445995 | 0.78 | ELANE (0.51) | THRBKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL16158571 | 0.78 | THRB (0.45) | THRBTGM2KMT2AMEN1MAPT | |
| SCHEMBL4596017 | 0.77 | THRB (1.00) | THRBKMT2AMEN1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080382-A1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS | Alcon Laboratories, Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999053347-A1 | HIGH REFRACTIVE INDEX OPHTHALMIC DEVICE MATERIALS | ALCON LABORATORIES, INC. (US) | 1999-10-21 | — | — | WO | disclosed |