Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PTAFR | P25105 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8135155 | 0.87 | ADORA3 (0.40) | ADORA3MAPTMAPK1TSHR | |
| SCHEMBL8138174 | 0.86 | ADORA3 (0.36) | ADORA3MAPTMAPK1TSHR | |
| SCHEMBL7872515 | 0.85 | ADORA3 (0.38) | ADORA3MAPTMAPK1GRM5TSHR | |
| SCHEMBL7872534 | 0.84 | ADORA3 (0.38) | ADORA3MAPTMAPK1TSHRTRPV1 | |
| SCHEMBL8135837 | 0.84 | ADORA3 (0.34) | ADORA3MAPTMAPK1TSHR | |
| SCHEMBL7871436 | 0.84 | TSHR (0.38) | ADORA3GRM5TSHR | |
| SCHEMBL7871376 | 0.83 | ADORA3 (0.37) | ADORA3MAPTMAPK1GRM5TSHR | |
| SCHEMBL7864225 | 0.83 | ADORA3 (0.41) | ADORA3MAPK1TSHR | |
| SCHEMBL7869604 | 0.83 | ADORA3 (0.40) | ADORA3MAPTMAPK1TSHR | |
| SCHEMBL7864174 | 0.83 | ADORA3 (0.37) | ADORA3MAPTMAPK1GRM5TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6306853-B1 | DICARBOXYLIC ESTER DERIVATIVES OF DIHYDROPYRIDINE COMPOUNDS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-10-23 | — | — | US | disclosed |
| EP-1055672-A1 | 1,4-DIHYDROPYRIDINE DERIVATIVES | Nikken Chemicals Company, Limited (JP) | 2000-11-29 | — | — | EP | disclosed |