SCHEMBL7872269

SCHEMBL7872269

FC(F)(F)c1cc(C(F)(F)F)c(C(F)(F)F)c(C(F)(F)F)c1I

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SOS1 Q07889 1/20 0.32
NOTUM Q6P988 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23416481 0.81 GAA (0.35)
SCHEMBL7879895 0.74 NOTUM (0.33) NOTUM
SCHEMBL16554018 0.72 NOTUM (0.37) NOTUM
SCHEMBL21490255 0.70 ERN1 (0.37)
SCHEMBL16554203 0.69 CES2 (0.40)
SCHEMBL21490252 0.69 ERN1 (0.35)
SCHEMBL6754916 0.67 POLB (0.41) NOTUM
SCHEMBL7882956 0.67 CES2 (0.35) NOTUM
SCHEMBL5795608 0.66 POLB (0.36) NOTUM
SCHEMBL21490272 0.65 KIF11 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6326517-B1 REACTIN AN AROMATIC COMPOUND WITH CARBON MONOXIDE AND AMMONIA CENTRAL GLASS COMPANY, LIMITED (JP) 2001-12-04 US disclosed
US-6268527-B1 REACTING TRIFLUOROMETHYL SUBSTITUTED AROMATIC COMPOUND WITH CARBON MONOXIDE AND HYDROXY COMPOUND IN PRESENCE OF METAL COMPOUND AND PHOSPHINE DERIVATIVE TO PRODUCE TRIFLUOROMETHYL SUBSTITUTED BENZOIC ACID DERIVATIVE CENTRAL GLASS COMPANY, LIMITED (JP) 2001-07-31 US disclosed