Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979034 | 1.00 | OPRL1 (0.42) | OPRL1MCHR1OPRM1OPRD1OPRK1 | |
| SCHEMBL8508323 | 1.00 | OPRL1 (0.42) | OPRL1MCHR1OPRM1OPRD1OPRK1 | |
| SCHEMBL6974165 | 1.00 | OPRL1 (0.42) | OPRL1MCHR1OPRM1OPRD1OPRK1 | |
| SCHEMBL6974169 | 1.00 | OPRL1 (0.42) | OPRL1MCHR1OPRM1OPRD1OPRK1 | |
| SCHEMBL7835369 | 0.89 | MCHR1 (0.39) | OPRL1MCHR1OPRM1OPRD1OPRK1 | |
| SCHEMBL6982504 | 0.89 | HRH3 (0.34) | MCHR1HRH3KDM4EPOLBKMT2A | |
| SCHEMBL8475345 | 0.89 | HRH3 (0.34) | MCHR1HRH3KDM4EPOLBKMT2A | |
| SCHEMBL6982502 | 0.89 | HRH3 (0.34) | MCHR1HRH3KDM4EPOLBKMT2A | |
| SCHEMBL6981689 | 0.87 | SLC6A9 (0.36) | OPRL1MCHR1OPRM1OPRD1OPRK1 | |
| SCHEMBL8473770 | 0.87 | SLC6A9 (0.36) | OPRL1MCHR1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313302-B2 | OPIOID KAPPA RECEPTOR ANTAGONISTS; SIDE EFFECT REDUCTION; ANALGESICS, ANTIINFLAMMATORY AGENTS, ANESTHETICS, AND NEUROPROTECTANTS | PFIZER INC. | 2001-11-06 | — | — | US | disclosed |