Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.52 |
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | MEP1B | Q16820 | 3/20 | 0.48 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867578 | 1.00 | RAB9A (0.52) | RAB9ASMN1; SMN2MRGPRX4TP53NFKB1 | |
| Cyclopropane Carboxylic Acid SCHEMBL7867647 | 0.91 | ALDH1A1 (0.49) | RAB9ASMN1; SMN2MRGPRX4TP53NFKB1 | |
| SCHEMBL5372 | 0.79 | MIF (0.67) | SMN1; SMN2TP53KDM4EMIF | |
| Phenylacetic Acid SCHEMBL7872638 | 0.76 | KDM4E (0.52) | RAB9ASMN1; SMN2TP53NPC1AKR1C3 | |
| SCHEMBL27661227 | 0.76 | FOLH1 (0.56) | SMN1; SMN2MRGPRX4MEP1BMEP1AKMT2A | |
| SCHEMBL30885594 | 0.76 | FOLH1 (0.56) | SMN1; SMN2MRGPRX4MEP1BMEP1AKMT2A | |
| SCHEMBL16162272 | 0.74 | NPC1 (0.55) | RAB9ASMN1; SMN2TP53NFKB1NFKB2 | |
| SCHEMBL18773942 | 0.73 | KMT2A (0.84) | RAB9ASMN1; SMN2TP53NPC1GAA | |
| SCHEMBL27657933 | 0.73 | ALDH1A1 (0.50) | SMN1; SMN2TP53MEP1BGAAMEN1 | |
| SCHEMBL31674610 | 0.73 | MRGPRX4 (0.71) | RAB9ASMN1; SMN2MRGPRX4TP53NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316623-B1 | USEFUL FOR SCREENING IN BIOLOGICAL ASSAYS IN ORDER TO IDENTIFY PHARMACEUTICALLY USEFUL COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2001-11-13 | — | — | US | disclosed |