Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL80316 | 0.91 | ALDH1A1 (0.60) | ALDH1A1MAPTSMN1; SMN2L3MBTL1BCL2L1 | |
| Biphenyl SCHEMBL8855942 | 0.91 | ALDH1A1 (0.60) | ALDH1A1MAPTSMN1; SMN2L3MBTL1BCL2L1 | |
| Biphenyl SCHEMBL28026828 | 0.88 | ALDH1A1 (0.56) | ALDH1A1MAPTSMN1; SMN2L3MBTL1BCL2L1 | |
| Biphenyl SCHEMBL7871061 | 0.85 | ALDH1A1 (0.60) | ALDH1A1MAPTSMN1; SMN2L3MBTL1BCL2L1 | |
| Biphenyl SCHEMBL7871199 | 0.82 | CYP3A4 (0.57) | ALDH1A1MAPTSMN1; SMN2L3MBTL1BCL2L1 | |
| Biphenyl SCHEMBL4386499 | 0.82 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2BCL2L1MMP3 | |
| Biphenyl SCHEMBL7874616 | 0.82 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2BCL2L1MMP3 | |
| Biphenyl SCHEMBL7865548 | 0.82 | ALDH1A1 (0.64) | ALDH1A1MAPTSMN1; SMN2BCL2L1MMP3 | |
| Biphenyl SCHEMBL20583591 | 0.80 | ALDH1A1 (0.53) | ALDH1A1MAPTSMN1; SMN2L3MBTL1BCL2L1 | |
| Biphenyl SCHEMBL8165523 | 0.79 | ALDH1A1 (0.60) | ALDH1A1MAPTSMN1; SMN2L3MBTL1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316575-B1 | MELT TRANSESTERIFICATION OF DIOL COMPOUND AND CARBOANTE COMPOUND USING CATALYST COMPRISING A PHOSPHORUS-CONTAINING BASIC COMPOUND QUATERNARY PHOSPHONIUM SALT TO FORM POLYCARBONATE | IDEMITSU KOSAN CO., LTD. (JP) | 2001-11-13 | — | — | US | claimed |