Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3373766 | 0.84 | LMNA (0.68) | LMNASMN1; SMN2L3MBTL1NPSR1MEN1 | |
| SCHEMBL373329 | 0.82 | LMNA (0.52) | LMNASMN1; SMN2L3MBTL1NPSR1OPRM1 | |
| SCHEMBL15630668 | 0.82 | ALDH1A1 (0.64) | LMNASMN1; SMN2L3MBTL1NPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7801197 | 0.81 | LMNA (0.51) | LMNASMN1; SMN2L3MBTL1NPSR1OPRM1 | |
| SCHEMBL27719893 | 0.78 | LMNA (0.59) | LMNASMN1; SMN2L3MBTL1NPSR1MEN1 | |
| SCHEMBL14513353 | 0.76 | DRD3 (0.53) | LMNASMN1; SMN2L3MBTL1NPSR1OPRM1 | |
| SCHEMBL3937184 | 0.76 | NPFFR1 (0.66) | LMNAL3MBTL1OPRL1DRD3MEN1 | |
| SCHEMBL8353279 | 0.74 | TSHR (0.54) | LMNASMN1; SMN2L3MBTL1NPSR1OPRM1 | |
| SCHEMBL6867538 | 0.73 | MAOA (0.45) | LMNASMN1; SMN2L3MBTL1NPSR1OPRM1 | |
| SCHEMBL6158885 | 0.73 | POLB (0.57) | OPRM1OPRL1HSD17B10CNR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808303-B1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ASTRAZENECA AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| EP-0808303-A1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024582-A1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1996-08-15 | — | — | WO | disclosed |