⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868283 | 0.85 | — | — | |
| SCHEMBL1496346 | 0.72 | ATM (0.32) | — | |
| SCHEMBL5894548 | 0.71 | CA12 (0.31) | — | |
| SCHEMBL199205 | 0.66 | SIGMAR1 (0.36) | — | |
| SCHEMBL5800131 | 0.65 | TNF (0.34) | — | |
| SCHEMBL5894630 | 0.65 | METAP1 (0.32) | — | |
| SCHEMBL1747903 | 0.62 | KDM4A (0.31) | — | |
| SCHEMBL18987 | 0.60 | CYP1A2 (0.39) | — | |
| SCHEMBL16317 | 0.60 | KDM4A (0.32) | — | |
| SCHEMBL27606375 | 0.59 | CYP1A2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794955-B1 | HINDERED N-OXIDE ESTERS OF RAPAMYCIN AND THEIR USE AS MEDICAMENTS | AMERICAN HOME PROD (US) | 2001-07-25 | — | — | EP | claimed |
| US-5559122-A | Hindered N-oxide esters of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-24 | — | — | US | claimed |
| US-5508290-A | Hindered N-oxide esters of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-04-16 | — | — | US | claimed |
| US-5491231-A | Hindered N-oxide esters of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-02-13 | — | — | US | claimed |
| EP-0794955-B1 | HINDERED N-OXIDE ESTERS OF RAPAMYCIN AND THEIR USE AS MEDICAMENTS | AMERICAN HOME PROD (US) | 2001-07-25 | — | — | EP | disclosed |
| EP-0794955-A1 | HINDERED N-OXIDE ESTERS OF RAPAMYCIN AND THEIR USE AS MEDICAMENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-17 | — | — | EP | disclosed |
| US-5559122-A | Hindered N-oxide esters of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-24 | — | — | US | disclosed |
| WO-1996016967-A1 | HINDERED N-OXIDE ESTERS OF RAPAMYCIN AND THEIR USE AS MEDICAMENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-06-06 | — | — | WO | disclosed |
| US-5521194-A | Hindered N-oxide esters of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-05-28 | — | — | US | disclosed |
| US-5508285-A | Hindered N-oxide esters of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-04-16 | — | — | US | disclosed |
| US-5508290-A | Hindered N-oxide esters of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-04-16 | — | — | US | disclosed |
| US-5491231-A | Hindered N-oxide esters of rapamycin | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-02-13 | — | — | US | disclosed |