Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GLS | O94925 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7868121 | 0.82 | MAPK1 (0.50) | TGM2SMN1; SMN2HTTKEAP1NFE2L2 | |
| SCHEMBL7868065 | 0.79 | MAPK1 (0.48) | TGM2SMN1; SMN2HTTKEAP1NFE2L2 | |
| SCHEMBL7873416 | 0.77 | ANPEP (0.49) | TGM2SMN1; SMN2HTTKEAP1NFE2L2 | |
| SCHEMBL28085520 | 0.74 | TGM2 (0.67) | TGM2SMN1; SMN2HTTKEAP1NFE2L2 | |
| SCHEMBL7976783 | 0.73 | TGM2 (0.65) | TGM2SMN1; SMN2HTTKEAP1NFE2L2 | |
| SCHEMBL18254066 | 0.72 | HTT (0.81) | TGM2SMN1; SMN2HTTKEAP1NFE2L2 | |
| SCHEMBL7348870 | 0.72 | TGM2 (0.61) | TGM2SMN1; SMN2HTTKEAP1NFE2L2 | |
| SCHEMBL3725943 | 0.71 | HTT (0.67) | TGM2SMN1; SMN2HTTKEAP1NFE2L2 | |
| SCHEMBL9874334 | 0.71 | HTT (0.79) | TGM2SMN1; SMN2HTTKEAP1NFE2L2 | |
| SCHEMBL15346534 | 0.71 | HTT (0.79) | TGM2SMN1; SMN2HTTKEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |