Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | STING1 | Q86WV6 | 3/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873394 | 0.80 | ALDH1A1 (0.49) | HTTLMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7873448 | 0.79 | MAPT (0.48) | HTTLMNASMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL7873367 | 0.77 | TGM2 (0.49) | ANPEPTGM2HTTFAAHKEAP1 | |
| SCHEMBL7879245 | 0.77 | RIOK2 (0.42) | L3MBTL1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7868121 | 0.76 | MAPK1 (0.50) | ANPEPTGM2HTTSTING1KEAP1 | |
| SCHEMBL7868172 | 0.75 | HPGD (0.42) | HTTKEAP1NFE2L2LMNASMN1; SMN2 | |
| SCHEMBL28085520 | 0.74 | TGM2 (0.67) | TGM2HTTFAAHKEAP1NFE2L2 | |
| SCHEMBL7868065 | 0.73 | MAPK1 (0.48) | ANPEPTGM2HTTSTING1KEAP1 | |
| SCHEMBL23566408 | 0.73 | MAPK1 (0.52) | HTTLMNASMN1; SMN2L3MBTL1POLB | |
| SCHEMBL7976783 | 0.73 | TGM2 (0.65) | ANPEPTGM2HTTFAAHKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |