Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ANPEP | P15144 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NLN | Q9BYT8 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | FPR1 | P21462 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9590000 | 0.88 | ANPEP (0.58) | ANPEPGAAHTTPOLBNPC1 | |
| SCHEMBL9602121 | 0.88 | ANPEP (0.58) | ANPEPGAAHTTPOLBNPC1 | |
| SCHEMBL20473201 | 0.82 | GAA (0.57) | TSHRGAAPKMAKT1ALDH1A1 | |
| SCHEMBL20473200 | 0.82 | GAA (0.57) | TSHRGAAPKMAKT1ALDH1A1 | |
| SCHEMBL7879302 | 0.82 | ANPEP (0.52) | ANPEPGAAPOLBNPC1RAB9A | |
| SCHEMBL7873337 | 0.81 | KMT2A (0.61) | ANPEPGAAPOLBNPC1RAB9A | |
| SCHEMBL7879201 | 0.81 | DHODH (0.49) | ANPEPGAAPOLBNPC1RAB9A | |
| SCHEMBL6248230 | 0.78 | PKM (0.50) | HTTPKMAKT1ALDH1A1LMNA | |
| SCHEMBL7357770 | 0.78 | PKM (0.50) | HTTPKMAKT1ALDH1A1LMNA | |
| SCHEMBL6248227 | 0.78 | PKM (0.50) | HTTPKMAKT1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |