Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ACACA | Q13085 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14714268 | 0.90 | ADRB2 (0.39) | RAB9ASMN1; SMN2NPC1LMNAMAPK1 | |
| SCHEMBL30344053 | 0.85 | ALDH1A1 (0.50) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL9317172 | 0.84 | POLB (0.58) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL8240521 | 0.80 | ATM (0.56) | SMN1; SMN2LMNAPOLBCYP1A2CYP2C9 | |
| SCHEMBL27733208 | 0.80 | ATM (0.56) | SMN1; SMN2LMNAPOLBCYP1A2CYP2C9 | |
| SCHEMBL8241135 | 0.80 | ATM (0.56) | SMN1; SMN2LMNAPOLBCYP1A2CYP2C9 | |
| SCHEMBL4448687 | 0.79 | SMN1; SMN2 (0.52) | RAB9ASMN1; SMN2NPC1HPGDL3MBTL1 | |
| SCHEMBL16054984 | 0.79 | ACACB (0.50) | ACACBPOLBACACACTSK | |
| SCHEMBL11632696 | 0.77 | LMNA (0.46) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL16055604 | 0.77 | SMN1; SMN2 (0.50) | RAB9ASMN1; SMN2NPC1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067928-A4 | METHODS FOR INHIBITING MRP1 | LILLY CO ELI (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-1067928-A1 | METHODS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999051228-A1 | METHODS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 1999-10-14 | — | — | WO | disclosed |