Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7870590 | 0.92 | MAPT (0.49) | MAPTGABRA5MEN1KMT2ABCL2L1 | |
| SCHEMBL7870523 | 0.92 | MEN1 (0.47) | MAPTGABRA5MEN1KMT2ABCL2L1 | |
| SCHEMBL7871575 | 0.91 | KMT2A (0.56) | MAPTMEN1KMT2ACA1CA2 | |
| SCHEMBL7862882 | 0.91 | EGFR (0.52) | MAPTMEN1KMT2ABCL2L1MCL1 | |
| SCHEMBL7869432 | 0.91 | EGFR (0.52) | MAPTMEN1KMT2ABCL2L1MCL1 | |
| SCHEMBL7870592 | 0.91 | MAPT (0.50) | MAPTGABRA5MEN1KMT2ABCL2L1 | |
| SCHEMBL7869433 | 0.91 | MAPT (0.50) | MAPTGABRA5MEN1KMT2ABCL2L1 | |
| SCHEMBL7874497 | 0.91 | MAPT (0.47) | MAPTGABRA5MEN1KMT2ABCL2L1 | |
| SCHEMBL7874604 | 0.91 | RAB9A (0.44) | MAPTGABRA5MEN1KMT2ACA1 | |
| SCHEMBL7867912 | 0.91 | EGFR (0.47) | GABRA5MEN1KMT2AEPHX2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |