Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 6/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.41 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.41 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867813 | 0.88 | PTGS2 (0.44) | RPA1PTGS2PTGS1TUBB4ATUBB | |
| SCHEMBL7876284 | 0.85 | PTGS2 (0.37) | RPA1PTGS2PTGS1ALDH1A1CYP1A2 | |
| SCHEMBL7878967 | 0.85 | PTGS2 (0.61) | RPA1PTGS2PTGS1TUBB4ATUBB | |
| SCHEMBL8201793 | 0.83 | PTGS2 (0.40) | RPA1PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL7867587 | 0.81 | PTGS2 (0.55) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL8199109 | 0.79 | SMN1; SMN2 (0.50) | RPA1PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL7872744 | 0.79 | RIPK2 (0.43) | RPA1PTGS2PTGS1TUBB4ATUBB | |
| SCHEMBL8642483 | 0.78 | NPC1 (0.50) | RPA1PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL8219128 | 0.76 | PTGS2 (0.48) | RPA1PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL8199732 | 0.75 | RPA1 (0.65) | RPA1MEN1KMT2ASMN1; SMN2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316485-B1 | INHIBITS ACTIVITY OF CYCLOOXYGENASE-2; FOR THERAPY AND PROPHYLAXIS OF INFLAMMATION, THROMBOSIS, RHEUMATOID ARTHRITIS, ALZHEIMER'S DISEASE; AS ANALGESIC | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| EP-1017678-A1 | 1,5-DIPHENYLPYRAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015505-A1 | 1,5-DIPHENYLPYRAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-04-01 | — | — | WO | disclosed |