Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17733595 | 0.67 | NAMPT (0.33) | HSP90AA1HSP90AB1GAANAMPT | |
| SCHEMBL17733614 | 0.64 | L3MBTL1 (0.33) | LMNAGAANAMPTALDH1A1KMT2A | |
| SCHEMBL20108321 | 0.63 | HSP90AA1 (0.34) | HSP90AA1HSP90AB1LMNAALDH1A1KMT2A | |
| SCHEMBL23747568 | 0.63 | NAMPT (0.30) | NAMPT | |
| SCHEMBL9436253 | 0.62 | HSP90AA1 (0.33) | HSP90AA1HSP90AB1LMNAGAANAMPT | |
| SCHEMBL23191901 | 0.62 | TDP1 (0.35) | LMNAGAANAMPTALDH1A1KMT2A | |
| SCHEMBL14540010 | 0.61 | HSD17B10 (0.35) | LMNAGAANAMPTALDH1A1KMT2A | |
| SCHEMBL17733547 | 0.61 | NAMPT (0.33) | HSP90AA1HSP90AB1LMNAGAANAMPT | |
| SCHEMBL22312264 | 0.60 | TDP1 (0.33) | LMNAGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL13591827 | 0.60 | HSP90AA1 (0.33) | HSP90AA1HSP90AB1GAANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |