Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | DDX3X | O00571 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7865767 | 0.85 | POLB (0.47) | ALDH1A1DDX3XMAPTMEN1KMT2A | |
| SCHEMBL17560500 | 0.82 | DDX3X (0.62) | ALDH1A1DDX3XSMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL14390573 | 0.81 | ALDH1A1 (0.58) | ALDH1A1DDX3XSMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL27112932 | 0.80 | MAOA (0.50) | ALDH1A1DDX3XSMN1; SMN2HDAC3HDAC1 | |
| Acetic Acid SCHEMBL27341484 | 0.80 | ALDH1A1 (0.67) | ALDH1A1DDX3XSMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL374432 | 0.80 | ALDH1A1 (1.00) | ALDH1A1DDX3XSMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL29557251 | 0.80 | ALDH1A1 (1.00) | ALDH1A1DDX3XSMN1; SMN2HDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL11427101 | 0.80 | DDX3X (0.60) | ALDH1A1DDX3XSMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL13478359 | 0.80 | ALDH1A1 (0.67) | ALDH1A1DDX3XSMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL7688047 | 0.80 | DDX3X (0.60) | ALDH1A1DDX3XSMN1; SMN2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37438-E1 | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. | 2001-11-06 | — | — | US | disclosed |
| US-5866612-A | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. (US) | 1999-02-02 | — | — | US | disclosed |
| EP-0799191-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019440-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-06-27 | — | — | WO | disclosed |