Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 10/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | PLG | P00747 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 2/20 | 0.36 |
| ▸ | PLAT | P00750 | 2/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2463176 | 0.85 | MTNR1A (0.60) | MTNR1AACHE | |
| SCHEMBL7865789 | 0.84 | ACHE (0.46) | MTNR1AACHE | |
| SCHEMBL7865790 | 0.82 | MTNR1A (0.42) | MTNR1AACHE | |
| SCHEMBL8306857 | 0.77 | NPC1 (0.44) | MTNR1AACHE | |
| SCHEMBL8308422 | 0.77 | ACHE (0.36) | MTNR1AACHEF2PLGPLAU | |
| SCHEMBL11746560 | 0.77 | MTNR1A (0.54) | MTNR1AACHE | |
| Hydrochloric Acid SCHEMBL8186897 | 0.76 | NPC1 (0.43) | ACHE | |
| SCHEMBL25413828 | 0.75 | ACHE (0.43) | MTNR1AACHE | |
| SCHEMBL7865753 | 0.75 | ACHE (0.46) | MTNR1AACHE | |
| Hydrochloric Acid SCHEMBL11748537 | 0.75 | MTNR1A (0.53) | MTNR1AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37438-E1 | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. | 2001-11-06 | — | — | US | disclosed |
| US-5866612-A | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. (US) | 1999-02-02 | — | — | US | disclosed |
| EP-0799191-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019440-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-06-27 | — | — | WO | disclosed |