Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.31 |
| ▸ | PLG | P00747 | 2/20 | 0.31 |
| ▸ | PLAU | P00749 | 2/20 | 0.31 |
| ▸ | PLAT | P00750 | 2/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310121 | 0.93 | ACHE (0.38) | ACHEMTNR1AF2PLGPLAU | |
| SCHEMBL8309882 | 0.83 | DRD2 (0.46) | — | |
| SCHEMBL8305510 | 0.80 | CA12 (0.34) | — | |
| SCHEMBL7513395 | 0.80 | MAOA (0.39) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL7517482 | 0.79 | MAOA (0.40) | PLAU | |
| SCHEMBL7510363 | 0.78 | CNR1 (0.41) | — | |
| SCHEMBL7521473 | 0.78 | CNR1 (0.41) | — | |
| SCHEMBL7506683 | 0.77 | F2 (0.42) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL7874968 | 0.77 | MTNR1A (0.44) | ACHEMTNR1AF2PLGPLAU | |
| SCHEMBL7518392 | 0.76 | F2 (0.41) | MTNR1AF2PLGPLAUPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892802-A1 | SPIRO(CYCLOPENT(B)INDOLE-PIPERIDINES) AND N-PHENYL-HYDRAZON INTERMEDIATES FOR THEIR PREPARATION, BOTH BEING ACETYLCHOLINESTERASE AND MAO INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-27 | — | — | EP | claimed |
| WO-1997037992-A2 | SPIRO[CYCLOPENT[B]INDOLE-PIPERIDINES] AND N-PHENYL-HYDRAZON INTERMEDIATES FOR THEIR PREPARATION, BOTH BEING ACETYLCHOLINESTERASE AND MAO INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-10-16 | — | — | WO | claimed |