SCHEMBL7875302

SCHEMBL7875302

CCCCNCc1cn(CCC(=O)NC(C)(C)c2ccc(Cl)cc2)cn1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 4/20 0.41
CNR2 P34972 4/20 0.41
SMN1; SMN2 Q16637 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
POLB P06746 1/20 0.39
CPB2 Q96IY4 7/20 0.35
TP53 P04637 1/20 0.35
HPGD P15428 2/20 0.34
HDAC3 O15379 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC2 Q92769 1/20 0.34
ALDH1A1 P00352 1/20 0.34
CPB1 P15086 3/20 0.33
PRCP P42785 1/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
NPC1 O15118 1/20 0.32
GLA P06280 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7877119 0.83 SMN1; SMN2 (0.40) CNR1CNR2SMN1; SMN2L3MBTL1POLB
SCHEMBL8446891 0.79 QPCTL (0.41) CNR1CNR2L3MBTL1POLBHPGD
SCHEMBL7876923 0.79 CNR1 (0.37) CNR1CNR2SMN1; SMN2L3MBTL1POLB
SCHEMBL9020863 0.75 SMN1; SMN2 (0.39) CNR1CNR2SMN1; SMN2L3MBTL1POLB
SCHEMBL8649217 0.75 SMN1; SMN2 (0.40) SMN1; SMN2L3MBTL1POLBHDAC3HDAC1
SCHEMBL8447455 0.75 L3MBTL1 (0.53) CNR1CNR2SMN1; SMN2L3MBTL1POLB
SCHEMBL8647413 0.74 CNR1 (0.33) CNR1CNR2SMN1; SMN2L3MBTL1POLB
SCHEMBL8446802 0.73 ALDH1A1 (0.55) CNR1CNR2SMN1; SMN2L3MBTL1POLB
SCHEMBL8444481 0.71 SMN1; SMN2 (0.50) SMN1; SMN2TP53
SCHEMBL8446189 0.71 ALDH1A1 (0.50) CNR1CNR2SMN1; SMN2L3MBTL1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6326500-B1 ANTIINFLAMMATORY AGENTS; ANTIALLERGENS ABBOTT LABORATORIES 2001-12-04 US disclosed
US-6215001-B1 ANTIINFLAMMATORY AGENTS, ANTIASTHMATICS, AND ANTIALLERGENS; SIDE EFFECT REDUCTION KNOLL AKTIENGESELLSCHAFT (DE) 2001-04-10 US disclosed
US-6031109-A Phenoxy-, phenylthio-, benzoyl-alkyleneaminoalkylene-imidazole derivatives as therapeutic agents KNOLL AKTIENGESELLSCHAFT (DE) 2000-02-29 US disclosed
US-5780642-A NON-STEROIDAL ANTIINFLAMMATORY AGENT WHICH BLOCKS RELEASE OF ARACHIDONIC ACID FROM PHOSPHOLIPIDS; SIDE EFFECT REDUCTION KNOLL AKTIENGESELLSCHAFT (DE) 1998-07-14 US disclosed
WO-1995000493-A1 IMIDAZOLE DERIVATIVES AS THERAPEUTIC AGENTS KNOLL AG (DE) 1995-01-05 WO disclosed