Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 20/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24313176 | 0.81 | HRH3 (0.45) | HRH3KCNH2CYP2D6 | |
| SCHEMBL19004863 | 0.74 | ALDH1A1 (0.61) | HRH3KCNH2CYP2D6 | |
| SCHEMBL20315424 | 0.74 | ALDH1A1 (0.67) | HRH3KCNH2CYP2D6 | |
| SCHEMBL104632 | 0.73 | HRH3 (0.63) | HRH3KCNH2CYP2D6 | |
| SCHEMBL13503770 | 0.73 | ALDH1A1 (0.70) | HRH3KCNH2CYP2D6 | |
| SCHEMBL14453913 | 0.72 | HRH3 (0.66) | HRH3KCNH2CYP2D6 | |
| SCHEMBL17789642 | 0.70 | LMNA (0.56) | HRH3KCNH2CYP2D6 | |
| SCHEMBL9424197 | 0.68 | — | — | |
| SCHEMBL2926694 | 0.68 | HRH3 (0.56) | HRH3KCNH2CYP2D6 | |
| SCHEMBL2924520 | 0.68 | HRH3 (0.56) | HRH3KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |