Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC42 | P60953 | 3/20 | 0.46 |
| ▸ | RAC1 | P63000 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17361251 | 1.00 | CDC42 (0.46) | CDC42RAC1PTGS2PTGS1NPC1 | |
| Biphenyl SCHEMBL27297012 | 0.93 | CDC42 (0.46) | CDC42RAC1PTGS2PTGS1NPC1 | |
| SCHEMBL11201877 | 0.89 | CDC42 (0.41) | CDC42RAC1PTGS2PTGS1NPC1 | |
| SCHEMBL11197597 | 0.88 | CDC42 (0.40) | CDC42RAC1PTGS2PTGS1NPC1 | |
| SCHEMBL30128755 | 0.84 | CDC42 (0.43) | CDC42RAC1PTGS2PTGS1NPC1 | |
| SCHEMBL7873890 | 0.84 | ALDH1A1 (0.37) | CDC42RAC1PTGS2PTGS1NPC1 | |
| SCHEMBL9458684 | 0.79 | CDC42 (0.40) | CDC42RAC1PTGS2PTGS1NPC1 | |
| SCHEMBL9383103 | 0.76 | KDM4E (0.40) | ALDH1A1KDM4EHTTLMNA | |
| SCHEMBL9381071 | 0.76 | CA12 (0.36) | ALDH1A1KDM4EMAPTTP53 | |
| SCHEMBL9381386 | 0.75 | ALDH1A1 (0.39) | CHRM3ALDH1A1KDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160081898-A1 | Compositions for Enhancing Nail Health | ALLERGAN INC (US) | 2016-03-24 | — | — | US | disclosed |
| US-9050262-B2 | Compositions for enhancing nail health | ALLERGAN, INC. (US) | 2015-06-09 | — | — | US | disclosed |
| EP-2763649-A2 | COMPOSITIONS FOR ENHANCING NAIL HEALTH | ALLERGAN, INC. (US) | 2014-08-13 | — | — | EP | disclosed |
| EP-2763650-A2 | COMPOSITIONS FOR ENHANCING NAIL HEALTH | ALLERGAN, INC. (US) | 2014-08-13 | — | — | EP | disclosed |
| US-20140079655-A1 | COMPOSITIONS FOR ENHANCING NAIL HEALTH | ALLERGAN, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-20130156713-A1 | COMPOSITIONS FOR ENHANCING NAIL HEALTH | ALLERGAN, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| WO-2013052380-A2 | COMPOSITIONS FOR ENHANCING NAIL HEALTH | ALLERGAN, INC. (US) | 2013-04-11 | — | — | WO | disclosed |
| WO-2013052424-A2 | COMPOSITIONS FOR ENHANCING NAIL HEALTH | ALLERGAN, INC. (US) | 2013-04-11 | — | — | WO | disclosed |
| US-20130089508-A1 | COMPOSITIONS FOR ENHANCING NAIL HEALTH | ALLERGAN, INC. (US) | 2013-04-11 | — | — | US | disclosed |
| US-20090253792-A1 | ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS | SHIRE LLC (US) | 2009-10-08 | — | — | US | disclosed |
| EP-0330283-A1 | Novel 5,6-diphenyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 1989-08-30 | — | — | EP | disclosed |
| EP-0297923-A1 | Benzodioxane prostacyclin analogues, their preparation and use | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1989-01-04 | — | — | EP | disclosed |
| EP-0284076-A1 | Process for preparing (+)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds | SYNTEX (U.S.A.) INC. (US) | 1988-09-28 | — | — | EP | disclosed |
| EP-0284076-A1 | Process for preparing (+)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds | SYNTEX (U.S.A.) INC. (US) | 1988-09-28 | — | — | EP | disclosed |
| EP-0284076-A1 | Process for preparing (+)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds | SYNTEX (U.S.A.) INC. (US) | 1988-09-28 | — | — | EP | disclosed |
| EP-0264429-A1 | ENZYMATIC PROCESS FOR PREPARING OPTICALLY-ACTIVE 1,2-DIHYDRO-3H-PYRROLO 1,2a]PYRROLE-1-CARBOXYLIC ACID DERIVATIVES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1988-04-27 | — | — | EP | disclosed |
| WO-1987006266-A1 | ENZYMATIC PROCESS FOR PREPARING OPTICALLY-ACTIVE 1,2-DIHYDRO-3H-PYRROLO[1,2a]PYRROLE-1-CARBOXYLIC ACID DERIVATIVES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1987-10-22 | — | — | WO | disclosed |
| EP-0041711-B1 | 6-CHLORO- OR 6-BROMO-1,2-DIHYDRO-3H-PYRROLO(1,2-A)-PYRROLE-1-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYNTEX (U.S.A.) INC. (US) | 1985-04-17 | — | — | EP | disclosed |
| EP-0096583-A2 | 5-Aroyl-1,2-dihydro-3H-pyrrolo 1,2-a pyrrole-1-carboxylic acids and derivatives thereof, processes for their preparation, and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1983-12-21 | — | — | EP | disclosed |
| US-4087539-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS, SMOOTH MUSCLE RELAXANTS | SYNTEX (U.S.A.) INC. (US) | 1978-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130089508-A1 | COMPOSITIONS FOR ENHANCING NAIL HEALTH | TYR, NACA, PIK3C3 | CDC42 540/4885RAC1 1330/4885PTGS2 3838/4885 |
| US-20090253792-A1 | ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS | HDGF, CTSA, IAPP | CDC42 1374/4885RAC1 1004/4885PTGS2 1417/4885 |
| US-20140079655-A1 | COMPOSITIONS FOR ENHANCING NAIL HEALTH | TYR, NACA, PIK3C3 | CDC42 540/4885RAC1 1330/4885PTGS2 3838/4885 |
| US-20130156713-A1 | COMPOSITIONS FOR ENHANCING NAIL HEALTH | TYR, NACA, PIK3C3 | CDC42 540/4885RAC1 1330/4885PTGS2 3838/4885 |
| US-20160081898-A1 | Compositions for Enhancing Nail Health | TYR, NACA, PIK3C3 | CDC42 540/4885RAC1 1330/4885PTGS2 3838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.