Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 4/20 | 0.34 |
| ▸ | RXRA | P19793 | 3/20 | 0.34 |
| ▸ | RXRG | P48443 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLA1 | P09884 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876283 | 0.79 | MAPT (0.47) | RAB9ANPC1TP53MAPTSMN1; SMN2 | |
| SCHEMBL4158770 | 0.76 | MEN1 (0.51) | RAB9ANPC1TP53MAPTSMN1; SMN2 | |
| SCHEMBL7876297 | 0.73 | TP53 (0.49) | ALDH1A1TP53MAPTSMN1; SMN2 | |
| SCHEMBL7876027 | 0.67 | GPR84 (0.47) | RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL26983383 | 0.66 | P2RX3 (0.37) | F2PRSS1PRSS2PRSS3CA1 | |
| SCHEMBL20564319 | 0.66 | PDE5A (0.39) | F2PRSS1PRSS2PRSS3RAB9A | |
| SCHEMBL20564252 | 0.65 | MAPK14 (0.47) | RXRBRXRARXRGRAB9ANPC1 | |
| SCHEMBL9720050 | 0.65 | TSHR (0.46) | RXRBRXRARXRGRAB9ANPC1 | |
| SCHEMBL20382692 | 0.64 | MAPT (0.52) | RAB9ANPC1ALDH1A1TP53MAPT | |
| SCHEMBL13939838 | 0.63 | GPR84 (0.47) | F2RAB9ANPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086122-A1 | PYRAZINONE PROTEASE INHIBITORS | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (US) | 2001-03-28 | — | — | EP | claimed |
| WO-1999064446-A1 | PYRAZINONE PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1999-12-16 | — | — | WO | claimed |