Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876520 | 0.73 | ALDH1A1 (0.42) | ALDH1A1HTTXBP1RAB9ATSHR | |
| SCHEMBL14815564 | 0.68 | IDO1 (0.46) | MAPK1MAPK14ALDH1A1HTTXBP1 | |
| SCHEMBL20706323 | 0.68 | IDO1 (0.49) | MAPK1MAPK14ALDH1A1HTTXBP1 | |
| SCHEMBL10786599 | 0.67 | IDO1 (0.40) | MAPK1MAPK14ALDH1A1HTTRAB9A | |
| SCHEMBL9515277 | 0.66 | IDO1 (0.44) | MAPK1MAPK14ALDH1A1HTTXBP1 | |
| SCHEMBL22808450 | 0.66 | IDO1 (0.50) | MAPK1MAPK14ALDH1A1HTTXBP1 | |
| SCHEMBL9004030 | 0.65 | IDO1 (0.49) | ALDH1A1HTTLMNATSHRBLM | |
| SCHEMBL5951346 | 0.65 | TSHR (0.47) | ALDH1A1HTTXBP1TSHRBLM | |
| SCHEMBL3394130 | 0.64 | PDPK1 (0.44) | MAPK1MAPK14ALDH1A1HTTRAB9A | |
| SCHEMBL30276343 | 0.64 | HTT (0.51) | ALDH1A1HTTLMNATSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |