Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.39 |
| ▸ | KDM5A | P29375 | 2/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7873347 | 0.76 | CA2 (0.40) | — | |
| SCHEMBL5951346 | 0.75 | TSHR (0.47) | ALDH1A1HTTXBP1KDM4CKDM5A | |
| SCHEMBL7876518 | 0.73 | MAPK1 (0.42) | ALDH1A1HTTXBP1RAB9ABLM | |
| SCHEMBL14632819 | 0.72 | CYP19A1 (0.45) | ALDH1A1HTTXBP1PDPK1 | |
| SCHEMBL3590904 | 0.72 | FFAR1 (0.52) | ALDH1A1HTTXBP1KDM4CKDM5A | |
| SCHEMBL30301824 | 0.72 | FFAR1 (0.52) | ALDH1A1HTTXBP1KDM4CKDM5A | |
| SCHEMBL6541484 | 0.71 | PRCP (0.53) | ALDH1A1 | |
| SCHEMBL9683763 | 0.70 | BLM (0.50) | ALDH1A1HTTXBP1KDM4CKDM5A | |
| SCHEMBL2995330 | 0.69 | CHRM1 (0.43) | PDPK1 | |
| SCHEMBL7038866 | 0.69 | HAO1 (0.53) | ALDH1A1HTTXBP1KDM4CKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |