Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | PKM | P14618 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876926 | 0.83 | NPC1 (0.53) | NPC1RAB9APKMGAASMN1; SMN2 | |
| SCHEMBL7877015 | 0.80 | NPC1 (0.53) | NPC1RAB9APKMGAASMN1; SMN2 | |
| SCHEMBL3890654 | 0.76 | GAA (0.49) | NPC1RAB9APKMTP53GAA | |
| SCHEMBL9586710 | 0.74 | NPC1 (0.56) | NPC1RAB9APKMTP53GAA | |
| SCHEMBL9586718 | 0.74 | NPC1 (0.56) | NPC1RAB9APKMTP53GAA | |
| SCHEMBL6056798 | 0.73 | RAB9A (0.50) | NPC1RAB9APKMTP53GAA | |
| SCHEMBL1147615 | 0.73 | NPC1 (0.63) | NPC1RAB9APKMGAASMN1; SMN2 | |
| SCHEMBL9080412 | 0.73 | NPC1 (0.63) | NPC1RAB9APKMGAASMN1; SMN2 | |
| SCHEMBL1185009 | 0.73 | NPC1 (0.63) | NPC1RAB9APKMGAASMN1; SMN2 | |
| SCHEMBL8889652 | 0.72 | NPC1 (0.46) | NPC1RAB9APKMTP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |