Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 8/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 8/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 8/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 8/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879884 | 0.80 | TP53 (0.33) | NPC1KMT2APDK1PDK2PDK3 | |
| SCHEMBL7868845 | 0.79 | KMT2A (0.41) | NPC1KMT2APDK1PDK2PDK3 | |
| SCHEMBL6840317 | 0.71 | FAAH (0.40) | KMT2APDK1PDK2PDK3PDK4 | |
| SCHEMBL697100 | 0.70 | PDK1 (0.39) | NPC1KMT2APDK1PDK2PDK3 | |
| SCHEMBL697653 | 0.67 | FAAH (0.37) | KMT2APDK1PDK2PDK3PDK4 | |
| SCHEMBL911935 | 0.67 | PDK1 (0.49) | NPC1PDK1PDK2PDK3PDK4 | |
| SCHEMBL711577 | 0.67 | FAAH (0.42) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL15958952 | 0.66 | PDK1 (0.48) | NPC1PDK1PDK2PDK3PDK4 | |
| SCHEMBL16590074 | 0.65 | NOTUM (0.59) | NPC1KMT2APDK1PDK2PDK3 | |
| SCHEMBL26079007 | 0.65 | NOTUM (0.59) | NPC1KMT2APDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010124082-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |
| WO-2010124086-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |
| WO-2010124114-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |
| WO-2010124119-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |
| WO-2010124116-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |