Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 7/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.46 |
| ▸ | PLAU | P00749 | 2/20 | 0.46 |
| ▸ | PLAT | P00750 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.45 |
| ▸ | KLK1 | P06870 | 6/20 | 0.44 |
| ▸ | KLK6 | Q92876 | 5/20 | 0.44 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | NOS2 | P35228 | 2/20 | 0.44 |
| ▸ | ABAT | P80404 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7202745 | 0.82 | NOS3 (0.46) | NOS3NOS1NOS2 | |
| SCHEMBL5080879 | 0.81 | LOXL2 (0.49) | LOXL2NOS3NOS1NOS2 | |
| SCHEMBL10668382 | 0.81 | SRC (0.52) | PLGKLKB1PLAUPLATPRSS1 | |
| SCHEMBL10668375 | 0.81 | TSHR (0.38) | — | |
| SCHEMBL327252 | 0.81 | LOXL2 (0.54) | LOXL2F10PLGKLKB1PLAU | |
| Hydrochloric Acid SCHEMBL7875006 | 0.80 | LOXL2 (0.47) | LOXL2NOS3NOS1NOS2 | |
| SCHEMBL14445095 | 0.79 | TSHR (0.37) | PLGKLKB1PLAUPLATPRSS1 | |
| SCHEMBL1146000 | 0.79 | SMN1; SMN2 (0.59) | SMYD3 | |
| Hydrochloric Acid SCHEMBL7443406 | 0.79 | LOXL2 (0.52) | LOXL2F10PLGKLKB1PLAU | |
| SCHEMBL17244567 | 0.79 | SMYD3 (0.45) | LOXL2PLGKLKB1PLAUSMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37438-E1 | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. | 2001-11-06 | — | — | US | disclosed |
| US-5866612-A | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. (US) | 1999-02-02 | — | — | US | disclosed |