Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 10/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7877535 | 0.99 | ALDH1A1 (0.39) | ALDH1A1EPHX1ACHESMN1; SMN2HPGD | |
| Bromide SCHEMBL7873157 | 0.84 | EPHX1 (0.35) | ALDH1A1EPHX1ACHESMN1; SMN2HPGD | |
| Bromide SCHEMBL8781004 | 0.80 | EPHX1 (0.34) | ALDH1A1EPHX1ACHESMN1; SMN2HPGD | |
| Hydrochloric Acid SCHEMBL8780964 | 0.80 | NPC1 (0.36) | ALDH1A1EPHX1ACHESMN1; SMN2HPGD | |
| SCHEMBL8195574 | 0.76 | EPHX1 (0.42) | ALDH1A1EPHX1ACHESMN1; SMN2HPGD | |
| SCHEMBL7877545 | 0.69 | ACHE (0.51) | ALDH1A1EPHX1ACHEATM | |
| SCHEMBL8382659 | 0.69 | EPHX1 (0.52) | ALDH1A1EPHX1ACHESMN1; SMN2HPGD | |
| Hydrochloric Acid SCHEMBL7877530 | 0.68 | ACHE (0.50) | ALDH1A1EPHX1ACHEATM | |
| SCHEMBL2551779 | 0.68 | EPHX1 (0.50) | ALDH1A1EPHX1ACHESMN1; SMN2HPGD | |
| SCHEMBL5128756 | 0.68 | EPHX1 (0.50) | ALDH1A1EPHX1ACHESMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37438-E1 | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. | 2001-11-06 | — | — | US | disclosed |
| US-5866612-A | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase | GLAXO WELLCOME INC. (US) | 1999-02-02 | — | — | US | disclosed |
| EP-0799191-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019440-A1 | ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-06-27 | — | — | WO | disclosed |