Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 11/20 | 0.59 |
| ▸ | DRD4 | P21917 | 8/20 | 0.59 |
| ▸ | DRD1 | P21728 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 10/20 | 0.59 |
| ▸ | HTR1A | P08908 | 4/20 | 0.59 |
| ▸ | HTR2C | P28335 | 2/20 | 0.59 |
| ▸ | CNR1 | P21554 | 2/20 | 0.57 |
| ▸ | PYGL | P06737 | 1/20 | 0.53 |
| ▸ | PYGM | P11217 | 1/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | PLD2 | O14939 | 1/20 | 0.50 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160955 | 0.80 | HTR1A (0.60) | DRD3DRD4DRD2HTR1A | |
| SCHEMBL25040904 | 0.79 | SETD2 (0.58) | DRD2HRH4 | |
| SCHEMBL2735833 | 0.76 | CNR1 (0.71) | CNR1PYGL | |
| SCHEMBL6662366 | 0.75 | NPC1 (0.52) | DRD3DRD4DRD2HTR1AHTR2C | |
| SCHEMBL5160839 | 0.75 | DRD2 (0.53) | DRD3DRD4DRD2HTR1AHTR2C | |
| SCHEMBL3082618 | 0.74 | DRD3 (1.00) | DRD3DRD4DRD1DRD2HTR1A | |
| SCHEMBL2735824 | 0.74 | NPC1 (0.67) | CNR1 | |
| SCHEMBL13753862 | 0.73 | HDAC3 (0.67) | DRD3DRD2CNR1HRH4 | |
| SCHEMBL7949981 | 0.73 | SNCA (0.59) | DRD3DRD2HTR1AHTR2CHTR2A | |
| SCHEMBL7950991 | 0.73 | NPC1 (0.61) | DRD3DRD4DRD2HTR1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323229-B1 | COMPOUNDS ARE USEFUL PSYCHOTHERAPEUTICS AND ARE POTENT AGONISTS AND/OR ANTAGONISTS OF THE SEROTONIN 1A (5-HT 1A) AND/OR SEROTONIN 1D (5-HT 1D) FOR TREATMENT OF HYPERTENSION, DEPRESSION, GENERALIZED ANXIETY DISORDER | PFIZER INC | 2001-11-27 | — | — | US | claimed |
| WO-2020183011-A1 | HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER | INSTITUT CURIE (FR) | 2020-09-17 | — | — | WO | disclosed |
| US-6323229-B1 | COMPOUNDS ARE USEFUL PSYCHOTHERAPEUTICS AND ARE POTENT AGONISTS AND/OR ANTAGONISTS OF THE SEROTONIN 1A (5-HT 1A) AND/OR SEROTONIN 1D (5-HT 1D) FOR TREATMENT OF HYPERTENSION, DEPRESSION, GENERALIZED ANXIETY DISORDER | PFIZER INC | 2001-11-27 | — | — | US | disclosed |
| US-6197773-B1 | HEADACHES; ANTIDEPRESSANTS | PFIZER INC | 2001-03-06 | — | — | US | disclosed |