Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.60 |
| ▸ | DRD2 | P14416 | 5/20 | 0.60 |
| ▸ | DRD4 | P21917 | 4/20 | 0.57 |
| ▸ | DRD3 | P35462 | 3/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160839 | 0.90 | DRD2 (0.53) | HTR1ADRD2DRD4DRD3NPC1 | |
| SCHEMBL6660894 | 0.86 | HCN1 (0.53) | HTR1ADRD2DRD4DRD3ADRA1A | |
| SCHEMBL5160692 | 0.86 | HTR1A (0.59) | HTR1AADRA1ARAB9A | |
| SCHEMBL6662366 | 0.84 | NPC1 (0.52) | HTR1ADRD2DRD4DRD3NPC1 | |
| SCHEMBL5160732 | 0.83 | NPC1 (0.51) | DRD2DRD4DRD3ADRA1ANPC1 | |
| Hydrochloric Acid SCHEMBL6664273 | 0.81 | NPC1 (0.49) | DRD2DRD4DRD3ADRA1ANPC1 | |
| SCHEMBL5160283 | 0.81 | HTR1A (0.48) | HTR1ADRD2DRD4DRD3ADRA1A | |
| SCHEMBL7879547 | 0.80 | KDM4E (0.48) | DRD2DRD4DRD3NPC1RAB9A | |
| SCHEMBL7877589 | 0.80 | DRD3 (0.59) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL5161023 | 0.79 | NPC1 (0.49) | HTR1ADRD2NPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952154-B1 | N-acyl and N-aroyl aralkyl amides | PFIZER PROD INC (US) | 2004-08-18 | — | — | EP | claimed |
| US-6323229-B1 | COMPOUNDS ARE USEFUL PSYCHOTHERAPEUTICS AND ARE POTENT AGONISTS AND/OR ANTAGONISTS OF THE SEROTONIN 1A (5-HT 1A) AND/OR SEROTONIN 1D (5-HT 1D) FOR TREATMENT OF HYPERTENSION, DEPRESSION, GENERALIZED ANXIETY DISORDER | PFIZER INC | 2001-11-27 | — | — | US | claimed |
| EP-0952154-A2 | N-acyl and N-aroyl aralkyl amides | Pfizer Products Inc. (US) | 1999-10-27 | — | — | EP | claimed |
| EP-1753460-A2 | COMBINATION OF ATYPICAL ANTIPSYCHOTICS AND 5-HT1B RECEPTOR ANTAGONISTS | Pfizer Products Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1737466-A1 | COMBINATION OF y-AMINOBUTYRIC ACID MODULATORS AND 5-HT-1b RECEPTOR ANTAGONISTS | Pfizer Products Inc. (US) | 2007-01-03 | — | — | EP | disclosed |
| EP-1703918-A2 | COMBINATION OF CRF ANTAGONISTS AND 5-HT 1B RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2006-09-27 | — | — | EP | disclosed |
| US-20050256112-A1 | Combination of atypical antipsychotics and 5HT-1B receptor antagonists | PFIZER INC | 2005-11-17 | — | — | US | disclosed |
| WO-2005107808-A2 | COMBINATION OF ATYPICAL ANTIPSYCHOTICS AND 5-HT1B RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-11-17 | — | — | WO | disclosed |
| WO-2005082372-A1 | COMBINATION OF γ-AMINOBUTYRIC ACID MODULATORS AND 5-HT 1B RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-09-09 | — | — | WO | disclosed |
| US-20050182049-A1 | Combination of gamma-aminobutyric acid modulators and 5-HT1B receptor antagonists | PFIZER INC | 2005-08-18 | — | — | US | disclosed |
| US-20050171095-A1 | Combination of CRF antagonists and 5-HT1B receptor antagonists | PFIZER INC | 2005-08-04 | — | — | US | disclosed |
| WO-2005067973-A2 | COMBINATION OF CRF ANTAGONISTS AND 5-HT 1B RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-07-28 | — | — | WO | disclosed |
| EP-0952154-B1 | N-acyl and N-aroyl aralkyl amides | PFIZER PROD INC (US) | 2004-08-18 | — | — | EP | disclosed |
| US-6451803-B1 | N-acyl and n-aroyl aralkyl amides useful in treating seritonergic disorders | PFIZER INC | 2002-09-17 | — | — | US | disclosed |
| US-6323229-B1 | COMPOUNDS ARE USEFUL PSYCHOTHERAPEUTICS AND ARE POTENT AGONISTS AND/OR ANTAGONISTS OF THE SEROTONIN 1A (5-HT 1A) AND/OR SEROTONIN 1D (5-HT 1D) FOR TREATMENT OF HYPERTENSION, DEPRESSION, GENERALIZED ANXIETY DISORDER | PFIZER INC | 2001-11-27 | — | — | US | disclosed |
| US-6197773-B1 | HEADACHES; ANTIDEPRESSANTS | PFIZER INC | 2001-03-06 | — | — | US | disclosed |
| EP-0952154-A2 | N-acyl and N-aroyl aralkyl amides | Pfizer Products Inc. (US) | 1999-10-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256112-A1 | Combination of atypical antipsychotics and 5HT-1B receptor antagonists | HTR1B, HTR2B, HTR3B | HTR1A 4/4885DRD2 49/4885DRD4 403/4885 |
| US-20050182049-A1 | Combination of gamma-aminobutyric acid modulators and 5-HT1B receptor antagonists | HTR1B, HTR2B, HTR2A | HTR1A 5/4885DRD2 259/4885DRD4 1208/4885 |
| US-20050171095-A1 | Combination of CRF antagonists and 5-HT1B receptor antagonists | HTR2B, HTR1B, HTR3B | HTR1A 8/4885DRD2 103/4885DRD4 743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.