Known targets — ChEMBL curated mechanism
DRD2DRD3DRD4GNRHRHRH1HTR2AHTR2CSLC6A2SLC6A4SSTR1SSTR2SSTR3SSTR5
The experimentally established mechanism targets of Pamoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.52 |
| ▸ | ME2 | P23368 | 1/20 | 0.44 |
| ▸ | ME1 | P48163 | 1/20 | 0.44 |
| ▸ | ME3 | Q16798 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.43 |
| ▸ | MEN1 | O00255 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | GALK1 | P51570 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pamoic Acid SCHEMBL7210346 | 0.86 | GPR35 (0.50) | POLBGPR35ME2ME1ME3 | |
| SCHEMBL7774855 | 0.81 | KMT2A (0.38) | KMT2AMEN1MAPK1KDM4EL3MBTL1 | |
| Pamoic Acid SCHEMBL517883 | 0.73 | POLB (0.81) | POLBGPR35ME2ME1ME3 | |
| SCHEMBL7210617 | 0.72 | PDE10A (0.43) | POLBKMT2AMEN1MAPTHPGD | |
| Pamoic Acid SCHEMBL30293211 | 0.72 | GPR35 (1.00) | POLBGPR35ME2ME1ME3 | |
| Pamoic Acid SCHEMBL5721 | 0.72 | GPR35 (1.00) | POLBGPR35ME2ME1ME3 | |
| Pamoic Acid SCHEMBL29362189 | 0.72 | GPR35 (1.00) | POLBGPR35ME2ME1ME3 | |
| Pamoic Acid SCHEMBL446833 | 0.72 | GPR35 (1.00) | POLBGPR35ME2ME1ME3 | |
| Pamoic Acid SCHEMBL30293206 | 0.72 | GPR35 (1.00) | POLBGPR35ME2ME1ME3 | |
| Pamoic Acid SCHEMBL7125175 | 0.72 | GPR35 (0.47) | POLBGPR35ME2ME1ME3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331549-B1 | TREATMENT OF URINARY STRESS INCONTINENCE, VENOUS INSUFFICIENCY, VENOUS ULCERS, MIGRAINE OR GASTROINTESTINAL DISORDERS | SANOFI-SYNTHELABO (FR) | 2001-12-18 | — | — | US | disclosed |