Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7883597 | 0.88 | ALDH1A1 (0.41) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL4363347 | 0.86 | ALDH1A1 (0.44) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL9566732 | 0.85 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL987234 | 0.83 | ALDH1A1 (0.42) | ALDH1A1HPGDKDM4EHTTRECQL | |
| Water SCHEMBL21776630 | 0.82 | ALDH1A1 (0.41) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL7298547 | 0.81 | ALDH1A1 (0.40) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL7883522 | 0.80 | ALDH1A1 (0.44) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL7883248 | 0.80 | GRM1 (0.37) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL8861128 | 0.80 | ALDH1A1 (0.40) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL8244423 | 0.77 | ALDH1A1 (0.48) | ALDH1A1HPGDKDM4EHTTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573218-B1 | 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use | SANKYO CO (JP) | 2001-03-07 | — | — | EP | disclosed |
| CN-1051766-C | Angiotensin II antagonist imidazole derivatives, their preparation and their theapeutic use | SANKYO CO (JP) | 2000-04-26 | — | — | CN | disclosed |
| US-5646171-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-07-08 | — | — | US | disclosed |
| US-5616599-A | HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER | SANKYO COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| CN-1085896-A | The Angiotensin II antagonist imidazole derivatives, their preparation and therepic use thereof | SANKYO CO (JP) | 1994-04-27 | — | — | CN | disclosed |
| EP-0573218-A2 | 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use | SANKYO COMPANY LIMITED (JP) | 1993-12-08 | — | — | EP | disclosed |