Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7883597 | 0.81 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDHTTRECQL | |
| SCHEMBL7885549 | 0.81 | LMNA (0.40) | GRM1ALDH1A1ESR1CHRM1TSHR | |
| SCHEMBL7878657 | 0.80 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDHTTRECQL | |
| SCHEMBL987234 | 0.80 | ALDH1A1 (0.42) | ALDH1A1TSHRKDM4EHPGDHTT | |
| Hydrochloric Acid SCHEMBL7889797 | 0.80 | LMNA (0.40) | GRM1ALDH1A1ESR1CHRM1TSHR | |
| SCHEMBL4363347 | 0.79 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDHTTRECQL | |
| SCHEMBL8861128 | 0.79 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDHTTRECQL | |
| Water SCHEMBL21776630 | 0.78 | ALDH1A1 (0.41) | ALDH1A1TSHRKDM4EHPGDHTT | |
| SCHEMBL7298547 | 0.77 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDHTTRECQL | |
| SCHEMBL7883601 | 0.73 | PDE2A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573218-B1 | 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use | SANKYO CO (JP) | 2001-03-07 | — | — | EP | disclosed |
| CN-1051766-C | Angiotensin II antagonist imidazole derivatives, their preparation and their theapeutic use | SANKYO CO (JP) | 2000-04-26 | — | — | CN | disclosed |
| US-5646171-A | HYPOTENSIVE AGENTS | SANKYO COMPANY, LIMITED (JP) | 1997-07-08 | — | — | US | disclosed |
| US-5616599-A | HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER | SANKYO COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| CN-1085896-A | The Angiotensin II antagonist imidazole derivatives, their preparation and therepic use thereof | SANKYO CO (JP) | 1994-04-27 | — | — | CN | disclosed |
| EP-0573218-A2 | 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use | SANKYO COMPANY LIMITED (JP) | 1993-12-08 | — | — | EP | disclosed |