Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | IKBKB | O14920 | 3/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7883261 | 0.86 | MAPT (0.34) | LMNAKMT2AHTTCYP3A4CYP1A2 | |
| SCHEMBL7876696 | 0.72 | MAPT (0.34) | LMNAKMT2ACYP3A4CYP1A2ALDH1A1 | |
| SCHEMBL7878669 | 0.72 | POLB (0.41) | LMNAMAPK1POLBKDM4EHPGD | |
| SCHEMBL27637298 | 0.70 | APP (0.40) | LMNAKMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL27541444 | 0.68 | MAPK14 (0.38) | MAPTL3MBTL1 | |
| SCHEMBL7203924 | 0.66 | AAK1 (0.39) | LMNAKMT2AALDH1A1HSD17B10 | |
| SCHEMBL11085866 | 0.65 | APP (0.36) | LMNAKMT2AHTTCYP2D6CYP2C9 | |
| SCHEMBL27571353 | 0.63 | MAPT (0.52) | LMNAKMT2ACYP3A4CYP1A2CYP2C9 | |
| SCHEMBL29198702 | 0.63 | SMN1; SMN2 (0.42) | LMNAKMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL27499603 | 0.63 | KMT2A (0.46) | LMNAKMT2ACYP1A2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1244542-C | Aromatic amine derivatives having NOS inhibitory effect | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2006-03-08 | — | — | CN | disclosed |
| US-6331553-B1 | INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0949242-A1 | AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-13 | — | — | EP | disclosed |