Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7883261 | 0.81 | MAPT (0.34) | MAPTKMT2ANPSR1MEN1LMNA | |
| SCHEMBL27612427 | 0.73 | NR1H2 (0.37) | KMT2AMEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL7876697 | 0.73 | HDAC1 (0.39) | — | |
| SCHEMBL7878665 | 0.72 | LMNA (0.34) | MAPTKMT2ANPSR1MEN1LMNA | |
| SCHEMBL27789721 | 0.69 | GRM1 (0.66) | MAPTKMT2AMEN1CYP1A2HSD17B10 | |
| Carbamic Acid SCHEMBL28814185 | 0.68 | TSHR (0.40) | MAPTKMT2ANPSR1MEN1LMNA | |
| SCHEMBL7203924 | 0.68 | AAK1 (0.39) | KMT2ALMNALTA4HALDH1A1HSD17B10 | |
| SCHEMBL6756986 | 0.68 | BRD4 (0.44) | MAPTHSD17B10 | |
| SCHEMBL27571927 | 0.67 | L3MBTL1 (0.40) | KMT2AMEN1ALDH1A1HSD17B10TSHR | |
| SCHEMBL1495845 | 0.67 | GRM1 (0.48) | MAPTKMT2ANPSR1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331553-B1 | INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0949242-A1 | AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-13 | — | — | EP | disclosed |