Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7878665 | 0.86 | LMNA (0.34) | MAPTMEN1KMT2ANPSR1HSD17B10 | |
| SCHEMBL7876696 | 0.81 | MAPT (0.34) | MAPTMEN1KMT2ANPSR1HSD17B10 | |
| SCHEMBL7883263 | 0.72 | HDAC1 (0.41) | MAPTKDM4EL3MBTL1LMNA | |
| SCHEMBL27612427 | 0.70 | NR1H2 (0.37) | MEN1KMT2AALDH1A1POLBL3MBTL1 | |
| SCHEMBL7203924 | 0.67 | AAK1 (0.39) | KMT2AHSD17B10ALDH1A1LMNA | |
| Carbamic Acid SCHEMBL28814185 | 0.67 | TSHR (0.40) | MAPTMEN1KMT2ANPSR1HSD17B10 | |
| SCHEMBL7047176 | 0.67 | ALDH1A1 (0.44) | MAPTMEN1KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL11085866 | 0.66 | APP (0.36) | MEN1KMT2AHSD17B10ALDH1A1KCNH2 | |
| SCHEMBL27514230 | 0.65 | ALDH1A1 (0.42) | MAPTMEN1KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL7878669 | 0.65 | POLB (0.41) | KDM4EPOLBHPGDMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331553-B1 | INHIBITORS OF NITRIC OXIDE SYNTHASE; TREATING CEREBROVASCULAR DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0949242-A1 | AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-13 | — | — | EP | disclosed |