Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515626 | 0.79 | NPC1 (0.53) | RAB9ANPC1SMN1; SMN2TP53KMT2A | |
| SCHEMBL7868094 | 0.75 | TP53 (0.57) | RAB9ANPC1SMN1; SMN2TP53KMT2A | |
| SCHEMBL5139472 | 0.75 | KMT2A (0.54) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL4229894 | 0.74 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL31536297 | 0.74 | KMT2A (0.50) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL11997717 | 0.74 | KMT2A (0.50) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL7873434 | 0.74 | KDM4E (0.38) | MAPTKMT2AKDM4EGAATHRB | |
| SCHEMBL7024674 | 0.73 | KDM4E (0.51) | RAB9ANPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL1076411 | 0.72 | KMT2A (0.49) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL30373344 | 0.72 | KMT2A (0.51) | RAB9ANPC1SMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |