Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 12/20 | 0.55 |
| ▸ | NPC1 | O15118 | 10/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | NAMPT | P43490 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7024674 | 0.81 | KDM4E (0.51) | KDM4EALDH1A1LMNAHTTRAB9A | |
| SCHEMBL7953476 | 0.78 | RECQL (0.61) | KDM4EALDH1A1LMNAHTTMEN1 | |
| SCHEMBL7876589 | 0.77 | KIT (0.40) | LMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL162008 | 0.76 | RAB9A (0.65) | TP53KDM4EALDH1A1LMNAHTT | |
| SCHEMBL29655934 | 0.76 | RAB9A (0.65) | TP53KDM4EALDH1A1LMNAHTT | |
| SCHEMBL7873434 | 0.75 | KDM4E (0.38) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14164232 | 0.75 | ALDH1A1 (0.71) | TP53KDM4EALDH1A1LMNAHTT | |
| SCHEMBL3263544 | 0.75 | ALDH1A1 (0.66) | TP53KDM4EALDH1A1LMNAHTT | |
| SCHEMBL8271548 | 0.75 | ALDH1A1 (0.66) | TP53KDM4EALDH1A1LMNAHTT | |
| SCHEMBL7879166 | 0.75 | RAB9A (0.50) | TP53KDM4EHTTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | claimed |
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |