Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7024674 | 0.77 | KDM4E (0.51) | KDM4EALDH1A1GAAMEN1MAPT | |
| SCHEMBL9017891 | 0.76 | HDAC1 (0.49) | KDM4EALDH1A1GLAGAAHDAC1 | |
| SCHEMBL7868094 | 0.75 | TP53 (0.57) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14357917 | 0.75 | HDAC1 (0.46) | KDM4EALDH1A1GLAGAAHDAC1 | |
| SCHEMBL7879166 | 0.74 | RAB9A (0.50) | KDM4EGAAMAPTTHRBKMT2A | |
| SCHEMBL28390904 | 0.74 | NAMPT (0.47) | KDM4EALDH1A1GLAGAA | |
| Hydrochloric Acid SCHEMBL5749683 | 0.73 | HDAC1 (0.45) | KDM4EALDH1A1GLAGAAHDAC1 | |
| Hydrochloric Acid SCHEMBL29373586 | 0.73 | HDAC1 (0.45) | KDM4EALDH1A1GLAGAAHDAC1 | |
| SCHEMBL7873436 | 0.72 | CIT (0.42) | KDM4EALDH1A1GLAGAAHDAC1 | |
| SCHEMBL15432248 | 0.72 | KDM4E (0.51) | KDM4EALDH1A1GLAGAAHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |